Configuration: Extend Displays Main Monitor: ASUS VZ229H via HDMI Secondary Monitor: ASUS VS198D-P via VGA PC: Dell Inspiron 3650 w/ a i5-6400, Intel HD Graphics 530, 12 GB RAM, Windows 10 Pro The one connected via HDMI randomly loses signal for a couple of seconds before coming back on, with no pattern to it. The one connected via VGA never loses signal. I did not see a repeat of this problem when connecting my monitor to my Wii U, but I did not leave it hooked up for very long. When switching to the Wii U's HDMI cable the monitor seems to lose signal less frequently (but it still happens) than with the monitor's included HDMI cable. I also lose signal less frequently (but once again, it still happens) when running single monitor mode as opposed to dual. I'm at my wit's end. If it's the PC's HDMI port, I might invest in a video card or return my PC.